Keep the caulk off you
If you have to use caulk on any project you will inevitably get some on hands, and from there on everything. I used to use a rag to clean hands while working, but soon the rag is spreading caulk too. Now I grab a package of tissues that dispense one by one and make each wipe a one-time use, then drop the tissue and move on. My hands stay clean and I just pick up the discarded tissues when I’m done with the caulk.